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WebTesting of New Drug Substances and Products (hereafter referred to as the parent guideline). 1.2 Background The parent guideline notes that the use of matrixing and bracketing can be applied, if justified, to the testing of new drug substances and products, but provides no further guidance on the subject. 1.3 Scope of the Guideline Webaimed to describe drug release from a matrix system was proposed by Huguchi in 1961 (31). Initially conceived for planar systems, it was then extended to different geometrics and porous systems (32). This model is based on the hypotheses that (i) initial drug concentration in the matrix is much higher than WebDrug Symptom Matrix CNS Depressant Inhalants PCP Cannabis CNS Stimulants Hallucinogens Narcotic Analgesics HGN Present None VERTICAL NYSTAGMUS … buy cheap sofas online