Fbw7 ythdf2
WebNov 21, 2014 · YTHDF2 consists of a C-terminal YTH domain (designated as YTH YTHDF2 ), which specifically binds to m 6 A-containing RNA (m 6 A-RNA) with a preference for those containing a consensus motif of... WebNational Center for Biotechnology Information
Fbw7 ythdf2
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WebFBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2. Xu F, Li J, Ni M, Cheng J, Zhao H, Wang S, Zhou X, Wu X The tumor suppressor FBW7 is the substrate recognition component of the SCF E3-ubiquitin ligase complex that mediates proteolytic degradation of various oncogenic proteins. WebDownload scientific diagram Regulation of m⁶A-modified mRNA stability by the FBW7-YTHDF2 cascade. a Induction of the mRNA m⁶A levels upon YTHDF2 depletion in OVCAR8and HEY cells. The RNA ...
WebMar 3, 2024 · Furthermore, YTHDF2 globally regulates the turnover of m6A-modified mRNAs, including the pro-apoptotic gene BMF. Conclusions Our study has … WebDec 11, 2024 · FBW7 and miR-145 decrease the YTHDF2 protein level, leading to OC suppression. circRAB11FIP1-mediated FTO transcription can promote autophagy via m6A demethylation of ATG5 and ATG7. NF-κB stimulation upregulates ALKBH5 to induce demethylation of NANOG, which can promote tumour stemness.
WebMar 9, 2024 · In a study on ovarian cancer, FBW7 counteracted the tumorigenic effect of YTHDF2 by inducing its proteasomal degradation . In addition, researchers have demonstrated that the m 6 A reader YTHDF1 acts on EIF3C mRNA, a subunit of the protein translation initiation factor EIF3, to enhance protein translation efficiency in ovarian … WebFBW7 counteracts the tumor-promoting effect of YTHDF2 by inducing proteasomal degradation of the latter in ovarian cancer. Furthermore, YTHDF2 globally regulates the turnover of m⁶A-modified ...
WebNov 12, 2024 · This study depicted the mechanism of YTHDF2 and FBW7 in OC; FBW7 could decrease the YTHDF2-mediated m 6 A-dependent mRNA decay for stabilizing the …
WebDec 11, 2024 · Recently, Xu et al. identified YTHDF2 as a novel substrate for E3-ubiquitin ligase (F-box and WD repeat domain containing 7) FBW7 in OC, the latter of which is a tumour suppressor . After degradation via the proteasome system, impaired YTHDF2 impinged on mRNA decay of the proapoptotic gene bcl2 modifying factor ( BMF ) in vitro … majan united security \u0026 safety llcWebWith a 2024 population of 490,270, it is the largest city in Georgia and the 39th largest city in the United States. Atlanta is currently declining at a rate of -0.63% annually and its … majan locationWebFeb 19, 2024 · The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different … majan telecommunication llcWebCurrent Weather. 5:11 AM. 47° F. RealFeel® 48°. Air Quality Excellent. Wind NE 2 mph. Wind Gusts 5 mph. Clear More Details. majans bhuja snacks ancient grain twistsmajan tours and travels muscatWebMar 29, 2024 · FBW7 suppresses ovarian cancer development by targeting the N(6)-methyladenosine binding protein YTHDF2. FTO regulates myoblast proliferation by … majan scents of omanWebHome - Springer majan shipping and transport co