Ginkgolic acid genotoxicity

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August undefined, 2024

WebOct 16, 2024 · Ginkgolic acid obtained as a sphingomyelin synthase inhibitor from a plant extract library inspired the concept of sphingolipid mimics. Ginkgolic acid-derived N-acyl anilines and ginkgolic acid 2-phosphate (GA2P) respectively mimic ceramide and sphingosine 1-phosphate (S1P) in structure and function.The GA2P-induced … WebJan 2, 2015 · Ginkgolic acid (15:1) is a major toxic component in extracts obtained from Ginkgo biloba (EGb) that has allergic and genotoxic effects. This study is the first to …

A critical review of ginkgolic acids in Ginkgo biloba leaf …

WebAug 17, 2024 · This review looked at the toxicity of ginkgolic acid (from in vitro and in vitro trials) as well as the technologies (such as adsorption/desorption, enzymatic … WebJan 5, 2024 · Genotoxicity of GBE includes induction of DNA double-strand breaks by a prooxidant mechanism, associated to activation of DNA damage signaling pathways, and inhibition of topoisomerase II. ... GBE inhibits SUMOylation, in which ginkgolic acid seems to be main active component as a result of its direct interaction with SUMO-activating … hand being forced

Evaluation of the cytotoxic and mutagenic potential of …

WebFeb 28, 2024 · In the urgent campaign to develop therapeutics against SARS-CoV-2, natural products have been an important source of new lead compounds. We herein identified two natural products, ginkgolic acid and anacardic acid, as inhibitors using a high-throughput screen targeting the SARS-CoV-2 papain-like protease (PLpro). Moreover, our study … WebGinkgolic acid. Allergy: Allergic contact dermatitis has been reported particularly to the fruit and nuts of female trees. Food poisoning has occured in Japan when too many nuts are eaten:. It appears to be caused by … handbell cards

Ginkgolic acids induce neuronal death and activate protein ... - PubMed

Cytotoxicity of ginkgolic acid in HepG2 cells and primary rat ...

WebNaturally occurring compound. Various pharmacological effects. Potent, cell-permeable protease and SUMO inhibitor (IC 60 = 90 nM, HIV-1 protease). Inhibits HIV-infection unlike related ginkgolides A ( ab142602) and B ( ab142603 ). Shows antiproliferative and apoptotic effects. Shows anxiolytic effects in vivo. Orally active. Web1) Safety: Watch Out for Ginkolic Acid! Most people aren’t aware that Ginkgo leaves contain a toxic compound, ginkgolic acid. Pharmaceutical-grade Ginkgo extract must contain … handbell cartoonsWebExamples of such compounds include terpene trilactones (ginkgolides), acylated flavonol glycosides (ginkgoghrelins), biflavones (ginkgetin), ginkgotides and ginkgolic acids. The extract of G. biloba leaf is used to prevent and/or treat cardiovascular diseases, while many ginkgo-derived compounds are currently at various stages of preclinical ... buses from durham to london

"WebJan 2, 2024 · The genotoxicity of a Ginkgo biloba leaf extract (obtained from Shanghai Xing Ling Science and Technology Pharmaceutical Co., Shanghai, ... The embryotoxic effects of ginkgolic acid were confirmed by comparing the LD50 values in fresh fertile … " - Ginkgolic acid genotoxicity

Ginkgolic acid genotoxicity

Characterization of Alkylphenol Components in

WebAug 17, 2024 · Ginkgo biloba leaf extract (EGb) is high in bioactive components (over 170), which are used in food additives, medicine, cosmetics, health products, and other sectors. Nonetheless, ginkgolic acids (GAs) in Ginkgo biloba (GB) have been identified as the primary source of EGb's adverse effects such as embryotoxicity, cytotoxicity, … WebBoth ginkgolic acid and anacardic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins, including p53, in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although both compounds are shown to inhibit ...

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WebDec 22, 2014 · A series of standard solutions of ginkgolic acid 13:0 in the range of 2 to 50 mg/L were analyzed with a correlation coefficient r = 0.9981 and relative standard deviation (n = 5) from 12.5 to 13.7 ... WebDec 22, 2014 · A series of standard solutions of ginkgolic acid 13:0 in the range of 2 to 50 mg/L were analyzed with a correlation coefficient r = 0.9981 and relative standard …

WebThe ginkgolic acids have allergenic, immunotoxic, and other undesirable effects, ... etc.); terpenoids such as ginkgolides A, B, C; and ginkgolic acid. The effect of Ginkgo biloba extract on dementia has been assessed by a large volume of controlled clinical trials but findings are inconsistent. Based on meta-analysis of 12 systematic reviews, ... WebJan 1, 2024 · Genotoxicity refers to the potential for an agent to cause DNA lesions that can result in cell death, or mutations which can lead to cancer, and is an important category in hazard identification studies. ... kaempferol, quercetin, and isorhamnetin), biflavones, proanthocyanidins, alkylphenols (i.e., ginkgolic acid), simple phenolic acids, 6 ...

WebJan 19, 2024 · BackgroundExcessive inflammation and increased apoptosis of macrophages contribute to organ damage and poor prognosis of sepsis. Ginkgolic acid … WebMay 28, 2024 · Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro. Lu. Med. Sci. Monit., Br293- 2012 Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Fukuda I, Ito A, Hirai G, Nishimura S, Kawasaki H, Saitoh H, Kimura K, Sodeoka M, Yoshida M. Chem Biol, (2):133-140 2009 ...

WebTo further assess the adverse properties of alkylphenols, different fractions derived from the decanter sludge were evaluated for their embryotoxic effects in the hen's egg test (HET). A fraction enriched for ginkgolic acids (16%) and biflavones (6.7%) was found to induce death of 50% of the chick embryos (LD50) at a dose of 1.8 mg/egg ...

WebJan 2, 2015 · Ginkgolic acids (GAs) are alkylphenols which can be found in the fruits and leaves of Ginkgo biloba L. (Ginkgoaceae) used in herbal teas, drugs and food … handbell casesWebOct 29, 2015 · Ginkgolic acid in nanomolar concentrations causes potentiation of I gly mediated by homomeric α1 GlyRs expressed in CHO cells. (A) Structure of ginkgolic acids from G.biloba used in this study.(B) Whole-cell currents induced by 30 μM glycine in control (black trace) and at the different time points of treatment of cells with 30 nM of ginkgolic … handbell cartsWebOct 26, 2016 · Ginkgo leaf is the most used form of supplement for cognitive ailments. The standardized extract formulation EGb 761 is a dietary supplement with proven benefit in several neurological and psychiatric conditions including memory decline in Alzheimer’s disease, schizophrenia and dementia. Ginkgolic acid (GA) is a component of this … buses from durham to peterleeWebDec 26, 2024 · Results. Our data showed that the proliferation inhibition rate of cells at each ginkgolic acid concentration was higher than that of the control group (P < 0.05), suggesting that GA has an inhibitory influence on the proliferation of OCa cells, in a dose-dependent way.GA was able to inhibit the proliferation rate and migration ability of OCa … handbell carolersWebNational Center for Biotechnology Information. 8600 Rockville Pike, Bethesda, MD, 20894 USA. Contact. Policies. FOIA. HHS Vulnerability Disclosure. National Library of … buses from durham to bishop aucklandWebApr 24, 2024 · That is because — as co-first author François Chassagne, Ph.D., explains — concentrated ginkgolic acid C15:1 is actually toxic to the skin itself. Huang herself notes that, even when she ate ... buses from durham to newcastle airportWebAug 1, 2024 · Antitumor effects of ginkgolic acid in human cancer cell occur via cell cycle arrest and decrease the Bcl-2/Bax ratio to induce apoptosis. ... Review of current and … buses from durham to sunderland