Protamine anaphylaxis
WebbBecause fatal reactions, often resembling anaphylaxis, have been reported with protamine sulfate, give protamine sulfate only when resuscitation techniques and treatment for anaphylactic shock are readily available. For additional information, consult the labeling of Protamine Sulfate Injection, USP, products. 11 Description WebbAnaphylaxis is a life-threatening reaction with respiratory, cardiovascular, cutaneous, or gastrointestinal manifestations resulting from exposure to an offending agent, usually a food, insect ...
Protamine anaphylaxis
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Webb1 juli 2011 · Basically all the administered drugs or substances may be potential causes of anaphylaxis. Among them, those reported the most in literature include hypnotics, opioids, local anesthetics, colloids, dye, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Iodinated Contrast Media (ICM), antiseptics, aprotinin, ethylene oxyde and formaldehyde, and … WebbAlthough development of protamine anaphylaxis is not limited to diabetics, those patients with diabetes that have used protamine containing insulin (NPH or protamine zinc) do have a slightly increased risk of anaphylaxis. Some less common reactions to protamine include pulmonary vasoconstriction, hypotension, and thrombus formation.
Webb1 juli 2024 · While protamine, owing to its isolation from salmon milt and homology with human sperm protamine, can trigger anaphylactic and anaphylactoid reactions in a small proportion of patients previously exposed to the peptide (e.g. diabetic patients), who are allergic to fish or have undergone a vasectomy, such reactions are unlikely to be … WebbBecause anaphylaxis to intravenous protamine apparently may occur by a variety of …
Webb9 juni 2024 · Protamine should not be used for bleeding that occurs without prior … Webb19 maj 2009 · Anaphylactic reactions to protamine in patients allergic to fish have been reported. The anaesthetic team were informed and the necessary precautions taken. We report on the outcome for our patient and also discuss other risk factors and the types of reactions that can result when an adverse reaction to protamine occurs. References
WebbAdministration of protamine sulfate can cause severe hypotensive and anaphylactoid reactions. Because fatal reactions, often resembling anaphylaxis, have been reported with protamine sulfate, it should be given only when resuscitation equipment and treatment of anaphylactic shock are readily available.
Webb25 mars 2024 · Mark Nguyen, PharmD Emergency Medicine Pharmacist Creator of PHARMWYZE, Host of the DAILY PHARMFAX Follow on your favorite social media platform @pharmwyze Washington State University College of ... lithium energy japanWebbInterventions. Ninety-five patients undergoing cardiac surgery were randomized prospectively into 3 groups. Group central vein control (CVC) and group central vein (CV) received protamine via a central vein over 10 minutes and 2 minutes, respectively. Group ascending aorta (AA) received protamine via the ascending aorta over 2 minutes. … lithium energy japan linkedinWebbProtamine is used widely to reverse the anticoagulant effects of heparin and to delay the … impulse therapy port moodyWebbAbstract. Adverse responses to protamine are most likely multifactorial in nature. … lithium energy limited stockWebb19 maj 2013 · Excessive amounts of protamine are not recommended due to increased postoperative blood loss. C. Idiosyncratic reactions: Severe anaphylactic reactions may occur in some patients resulting in profound vascular collapse. IV. TREATMENT OF CARDIOVASCULAR COLLAPSE: A. Primary Therapies: 1. Stop protamine administration … lithium engineeringWebbThese have been shown to have immunosuppressive effects on anaphylaxis by decreasing in vitro IgE receptor-mediated signaling and the degranulation of human mast cells ... For this reason, protamine-nAra h 2-CpG particles were prepared and injected SC into naïve BALB/c mice, showing an increase in Ara h 2-specific IgG2a with no detectable ... lithium engpassWebb29 juni 2015 · Pulmonary hypertension due to the localised vasoconstrictor activity of thromboxane, activated by an anaphylactoid reaction to protamine; Anaphylaxis (it is after all a fish product) Resistance to heparin therapy. There are situations in which vast quantities of IV heparin fail to increase the APTT in spite of your every effort. lithium english